CAS:56180-94-0| Acarbose

Introduction and application of CAS:56180-94-0| Acarbose

Its biosynthetic pathway can be summarized as the following three processes:
①Synthesis of aminocycloalcohols: 7-P-sedulose-7-phosphate gradually undergoes a series of processes such as intramolecular cyclization, epimerization, dehydrogenation, dehydration, phosphorylation, and nucleotidation. Enzymatic reaction produces NDP-1-epi-valienol-7-phosphate;
②Synthesis of 4-amino-4,6-dideoxyglucose: D-1-glucose-1-phosphate undergoes nucleotidation, dehydration, transamination and other reactions to generate dTDP-4-amino-4, 6-dideoxyglucose (dTDP-4-amino-4,6-dideoxy-D-glucose);
③Synthesis of acarbose: NDP-1-epi-valienol-7-phosphate and dTDP-4-amino-4,6-dideoxyglucose undergo a glycosyl transfer reaction under the action of glycosyltransferase to generate dTDP- acarvicose-7-phosphate, and then dTDPacarvicose-7-phosphate is directly combined with maltose molecules to generate acarbose-7-phosphate. The bacterial body completes the synthesis of acarbose-7-phosphate within the cell, but to finally generate acarbose, acarbose-7-phosphate needs to be further transported across the membrane to the outside of the cell through the transporter AcbWXY/GacWXY, and after dephosphorylation occurs Finally, acarbose is formed.
Chemical Properties Amorphous powder. [α]D18+165°(C=0.4, water).
Purpose Acarbose is an oligosaccharide that reversibly inhibits α-glycosidase activity on the brush border of the small intestinal mucosa, slowly reducing the rate of digestion of complex polysaccharides and sucrose, and thereby delaying glucose absorption. It is commonly used in insulin-dependent patients. and treatment of non-insulin-dependent diabetes mellitus.

Specification of CAS:56180-94-0| Acarbose

Melting point 165-170°C
Specific optical rotation D18+165°(c=0.4inwater)
Boiling point 675.05°C (roughestimate)
Density 1.4278 (roughestimate)
Refractive index 1.6000(estimate)
Storage conditions 2-8°C
Solubility: Very soluble in water, soluble in methanol, almost insoluble in methylene chloride.
Acidity coefficient (pKa)12.39±0.20(Predicted)
Color white to off-white water
SolubilitySolubleinwater.

Package of CAS:56180-94-0| Acarbose

25kg/1kg/drum

This product is valid for 24 months from the production date when stored in a warm sealed state.

Safety and Transportation

This product should be stored and sealed at room temperature. Customers should carefully read the product treatment, material safety data sheet (MSDS), and labels before use, be familiar with the product's safety information, operating instructions, and environmental impact, and wear appropriate personal protection as required. supplies.

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