Introduction and application of CAS No.76697-50-2 | 2-(Isopropylsulphonyl)aniline
2-(Isopropylsulphonyl)aniline (2-ISA) is a potent and selective inhibitor of the mitotic checkpoint kinase Mad2, which is implicated in cancer. 2-ISA has been shown to inhibit the mitotic spindle assembly checkpoint by binding to Mad2 and inhibiting its ability to phosphorylate Mad1 and Cdc20. In vitro experiments have demonstrated that 2-ISA blocks cell cycle progression in ht-29 cells, a colon cancer cell line, by preventing their entry into mitosis. 2-ISA has been shown to be an effective inhibitor of tumor growth in vivo. This agent also inhibits sorafenib, a drug that targets the Raf/MEK/ERK signaling pathway and is used for the treatment of cancer. The analogs of 2-ISA are being developed as potential anticancer agents.
Synonyms:
1-AMINO-2-(ISOPROPYLSULPHONYL)BENZENE;
1-Amino-2-(isopropylsulfonyl)benzene;
2-(Isopropylsulphonyl)aniline;
2-(Isopropylsulphonyl)aniline98%;
2-(isopropylsulfonyl)aniline;
2-(isopropylsulfonyl)benzenaMine;
2-(Propane-2-sulfonyl)-phenylaMine;
2-(Isopropylsulphonyl)aniline1-Amino-2-(isopropylsulfonyl)benzene
Specification of CAS No.76697-50-2 | 2-(Isopropylsulphonyl)aniline
|
ITEMS |
SPECIFICATION |
|
CAS |
76697-50-2 |
|
MF |
C9H13NO2S |
|
MW |
199.27 |
|
Boiling point |
381.1±34.0 °C(Predicted) |
|
Density |
1.194±0.06 g/cm3(Predicted) |
|
Melting point |
83.0 to 87.0 °C |
|
acidity coefficient(pKa) |
-0.79±0.10(Predicted) |
Package and transportation of Introduction and application of CAS No.76697-50-2 | 2-(Isopropylsulphonyl)aniline
Package:0.1g,1g,5g,25g,100g,500g,1kg
Transportation: by courier/ by air/ by sea
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