[English name]: 2-Thiobenzyl nicotinic acid
[CAS number]: 112811-90-2
[Main content]: 99.0%min
[Structural formula]:
| Melting point | 188-190°C |
| Boiling point | 431.1±40.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Storage conditions | 2-8°C |
| Form | powder to crystal |
| Acidity coefficient (pKa) | 1.56±0.36(Predicted) |
| Color | White to Almost white |
2-Thiobenzyl nicotinic acid is a synthetic compound that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. It is used in the treatment of tuberculosis. 2-Thiobenzyl nicotinic acid is synthesized from 2-chloronicotinic acid, which is prepared by reacting benzyl chloride and hydrazine. The synthesis process can be divided into two steps: first, the benzyl chloride reacts with hydrazine to form an intermediate, which undergoes an acid-catalyzed hydrolysis to produce 2-chloronicotinic acid; second, the 2-chloronicotinic acid reacts with thiourea to form 2-thiobenzyl nicotinic acid. It has been shown that this compound inhibits fungal and bacterial growth at concentrations of 10 μM or less.
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