CAS:938-24-9 | Indan-1,2,3-trione

Introduction of CAS:938-24-9 | indan-1,2,3-trione

Indan-1,2,3-trione , also known as 1H-Indene-1,2,3-trione , is an organic compound with the chemical formula C₆H₄(CO)₃ . It is the dehydrated derivative of ninhydrin , a well-known reagent used for revealing fingerprints. Ninhydrin is also employed in various fields, including agriculture, food sciences, chemistry, and medicine. Interestingly, ninhydrin can be considered as the hydrate of this compound. While most gem-hydroxyl compounds readily lose water molecules to form carbonyl or keto groups, ninhydrin exhibits an abnormal resistance to dehydration .

Specification of CAS:938-24-9 | indan-1,2,3-trione

Research Application of CAS:938-24-9 | indan-1,2,3-trione

Biological Activity and Therapeutic Potential

Indan-1,2,3-trione derivatives exhibit a wide range of biological activities, including antiviral, anti-inflammatory, analgesic, antimalarial, antibacterial, and anticancer properties. These compounds also show promise in the treatment of neurodegenerative diseases and are used as effective insecticides, fungicides, and herbicides. The comprehensive review by Turek et al. (2017) highlights over 100 synthetic methods for preparing 1-indanones, the core structure of this compound, demonstrating the compound's broad therapeutic and agricultural potential (Turek, Szczęsna, Koprowski, & Bałczewski, 2017).

Catalytic Applications

In the realm of catalysis, this compound and its derivatives play a significant role. Mahato et al. (2020) discuss the versatile applications of indium trichloride (InCl3), a catalyst related to this compound, in synthesizing a broad spectrum of heterocyclic compounds. InCl3 is recognized for its stability in moisture and aqueous media and is highly valued for synthesizing bioactive heterocyclic compounds (Mahato, Acharya, Wellington, Bhattacharjee, & Jaisankar, 2020).

Theranostic Applications in Oncology

Wang et al. (2018) reviewed the incorporation of Indocyanine green (ICG), a compound structurally related to this compound, into nanoparticles for cancer theranostics. These nanoparticles, when functionalized, can integrate multiple imaging and therapeutic techniques for enhanced cancer diagnosis and treatment. The review systematically summarizes the biodistribution of these nanoparticles and discusses their opportunities and limitations in cancer theranostics (Wang et al., 2018).

Photocatalysis for Environmental Applications

Soni et al. (2021) reviewed the photocatalytic applications of indium sulfide (In2S3), a compound structurally akin to this compound. The focus is on hydrogen production through water splitting and contaminant degradation, leveraging the narrow bandgap of In2S3 for visible light harnessing. The review covers the synthesis, performance enhancement strategies, and the potential environmental applications of In2S3-based photocatalysts (Soni, Raizada, Kumar, Hasija, Singal, Singh, Hosseini-Bandegharaei, Thakur, & Nguyen, 2021).

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