CAS:22468-26-4 | 4-Hydroxypyridine-2-carboxylic Acid

Introduction of CAS:22468-26-4 | 4-Hydroxypyridine-2-carboxylic acid

Hydroxypicolinic acid is a crystal - powder in physical form and its color ranges from white to very pale yellow . The compound is stable under normal conditions .

The synthesis of 4-Hydroxypicolinic acid involves the hydrolysis reaction of the nitrile group of the 4-alkoxy-3-hydroxypicolinonitriles . The starting picolinonitriles are typically suspended in a strong, aqueous mineral acid reaction medium and heated for a period of time at elevated temperature with good mixing .

Specification of CAS:22468-26-4 | 4-Hydroxypyridine-2-carboxylic acid

Research Application of CAS:22468-26-4 | 4-Hydroxypyridine-2-carboxylic acid

Chelation Behavior and Proton-Related Phenomena

4-Hydroxypicolinic acid has been studied for its kinetics and thermodynamics in proton-related reactions, using density functional theory. These studies have revealed preferences for certain forms (e.g., zwitterionic) over others in hydroxypicolinic acids, and provided insights into their complexation behaviors with metals like copper(II) (Yasarawan, Thipyapong, & Ruangpornvisuti, 2016).

Magnetic Properties and Complex Formation with Metals

Research on cobalt(II) complexes with hydroxypicolinic acids, including 3-hydroxypicolinic acid, highlights their magnetic properties and the structural characteristics of these complexes (Girginova et al., 2005). Similar studies have been conducted on cobalt(II) and other metal complexes, emphasizing their N,O-chelating coordination and crystal structures (Kukovec, Popović, Pavlović, & Linarić, 2008).

Antimicrobial Activities and DNA Interactions

4-Hydroxypicolinic acid derivatives have been characterized for their antimicrobial activities against various bacteria and fungi, and their interactions with DNA have been studied through molecular docking simulations (Tamer et al., 2018).

Lanthanide Luminescent Materials

The formation of new lanthanide complexes with 3-hydroxypicolinic acid for use in luminescent materials has been explored. These complexes are characterized by their photoluminescence and structural properties, making them promising for applications in nanocomposite materials (Soares-Santos et al., 2003).

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