CAS:112006-75-4 | 2-Aminosulfonyl-N,N-dimethylnicotinamide

Introduction of CAS:112006-75-4 | 2-Aminosulfonyl-N,N-dimethylnicotinamide

Synthesis Analysis

The synthesis of "2-Aminosulfonyl-N,N-dimethylnicotinamide" has been described through multiple methods, highlighting its accessibility for research and industrial applications. Peng Xue-wei (2011) detailed a synthesis route starting from 2-chloronicotinic acid, involving sulfhydrylation by thiourea to achieve a total yield of 58.1% (Peng Xue-wei, 2011). Sun Jian (2006) optimized the synthesis process to achieve a higher yield of 86%, marking a significant improvement over previous methods (Sun Jian, 2006).

Molecular Structure Analysis

The molecular structure of "2-Aminosulfonyl-N,N-dimethylnicotinamide" has been studied extensively. Research by Stéphane Turcotte et al. (2012) on N-Aminosulfamides, closely related to our compound of interest, explored the replacement of the C(α)H and the carbonyl of an amino acid residue with a nitrogen atom and a sulfonyl group, respectively. This research provides insights into the molecular structure and potential reactivity of such compounds (Stéphane Turcotte, Samir Bouayad‐Gervais, W. Lubell, 2012).

Specification of CAS:112006-75-4 | 2-Aminosulfonyl-N,N-dimethylnicotinamide

Research Application of CAS:112006-75-4 | 2-Aminosulfonyl-N,N-dimethylnicotinamide

Herbicide Intermediate: It's a key intermediate in the synthesis of the herbicide nicosulfuron. The optimization of its synthetic route has been a focus to increase yield and purity. Initial yields were around 58.1% but later improved to 86% (Peng Xue-wei, 2011; Sun Jian, 2006; Li Yan-long, 2010).

Biomedical Applications: The aminosulfonyl group plays a crucial role in selectivity of certain compounds towards enzyme inhibition, potentially useful in designing drugs targeting specific proteins or receptors (G. L. Grunewald et al., 1997).

Antibacterial and Antifungal Agents: Novel heterocyclic compounds incorporating the sulfamoyl moiety from 2-aminosulfonyl-N,N-dimethylnicotinamide show promising antibacterial and antifungal activities, suggesting its use in developing antimicrobial agents (E. Darwish et al., 2014).

Environmental Cleanup: The compound's derivatives, especially in the context of nicosulfuron, are of interest in environmental cleanup and biodegradation studies, highlighting its relevance in reducing pollution and aiding in soil remediation (Weisong Zhao et al., 2015).

Chemical Synthesis & Polymer Research: It has applications in developing new strategies for the synthesis of hyperbranched polymers and various other chemical compounds, showing its versatility in chemical engineering and materials science (D. Yan & Chao Gao, 2000).

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