CAS No.98549-88-3 |1h-Pyrrolo[2,3-b]pyridin-5-ol

Introduction and application of CAS No.98549-88-3 |1h-Pyrrolo[2,3-b]pyridin-5-ol

1h-Pyrrolo[2,3-b]pyridin-5-ol is a synthetic chemical that is used as an intermediate in the synthesis of the drug venetoclax. It has been shown to be an inhibitor of Bcl-2 and is a fluorine-containing heterocycle. The chemical is synthesized by reacting 2,4,6-trifluoroacetic acid with 1H-pyrrole in the presence of Grignard reagent and trimethylchlorosilane.

The reaction intermediates are then purified and converted into 1h-pyrrolo[2,3-b]pyridin-5-ol using trifluoroacetic acid and hydrochloric acid. Impurities can be removed by recrystallization or distillation. 1h-Pyrrolo[2,3-b]pyridin-5-ol is industrially manufactured by reacting

Synonyms:

1H-PYRROLO[2,3-B]PYRIDIN-5-OL;

Specification of CAS No.98549-88-3 |1h-Pyrrolo[2,3-b]pyridin-5-ol

Package and transportation of Introduction and application of CAS No.98549-88-3 |1h-Pyrrolo[2,3-b]pyridin-5-ol

Package:0.1g,1g,5g,25g,100g,500g,1kg

Transportation: by courier/ by air/ by sea

Related Articles of CAS No.98549-88-3 |1h-Pyrrolo[2,3-b]pyridin-5-ol

Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton

B Wang, W Feng, J Wang, Y Dong, Y Liu, Y Yao… - Bioorganic & Medicinal …, 2021 - Elsevier

… by starting from commercially available tert-butyl 4-bromo-2-fluorobenzoate (7), which was

reacted with 1H-pyrrolo[2,3-b]pyridin-5-ol in the presence of NaOBu-t to give intermediate 8. …

Hot Tags: cas no.98549-88-3 |1h-pyrrolo[2,3-b]pyridin-5-ol, China cas no.98549-88-3 |1h-pyrrolo[2,3-b]pyridin-5-ol manufacturers, factory, Pharmaceutical Intermediates, Methyl toluenesulfonate, 4 Amino 4H 1 2 4 triazole, 3 deoxy adenosin, Cordycepin, Cellulose Acetate Butyrate