Introduction and application of CAS No.873054-44-5 | Ivacaftor
Activates CFTR channels.
Ivacaftor (trade name Kalydeco, developed as VX-770) is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% cases of cystic fibrosis, and is included in a combination drug, lumacaftor/ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR.
Synonyms:
VX770,VX 770,Ivacaftor;Ivacaftor;[14C]-Ivacaftor;
N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide;
Kalydeco;VX770;Ivacaftor (VX-770);UNII-1Y740ILL1Z;
N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxaraide;
N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide;
N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide;
N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide;
Specification of CAS No.873054-44-5 | Ivacaftor
|
ITEMS |
SPECIFICATION |
|
CAS |
873054-44-5 |
|
MF |
C24H28N2O3 |
|
MW |
392.49 |
|
Melting point |
212-215°C |
|
Boiling point |
550.4±50.0 °C(Predicted) |
|
Density |
1.187 |
|
acidity coefficient(pKa) |
11.08±0.23(Predicted) |
Package and transportation of Introduction and application of CAS No.873054-44-5 | Ivacaftor
Package:0.1g,1g,5g,25g,100g,500g,1kg
Transportation: by courier/ by air/ by sea
Related Articles of CAS No.873054-44-5 | Ivacaftor
Ivacaftor
PB Davis, U Yasothan, P Kirkpatrick - Nature reviews Drug discovery, 2012 - go.gale.com
… by 10.6 percentage points in the ivacaftor group compared with the placebo group in …
ivacaftor group compared with the placebo group in trial 2 (REFS 3,4). Patients receiving ivacaftor …
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