Introduction and application of CAS No.53949-53-4 | 1-Hydroxyibuprofen
Degradation product of Ibuprofen. Ibuprofen impurity L.
Ibuprofen is a nonsteroidal anti-inflammatory drug that is used to treat arthritis, rheumatoid arthritis, menstrual cramps and pain. Ibuprofen is a racemic mixture of two enantiomers, ibuprofen and S (+) -ibuprofen. The dextran sulfate method is an analytical method used to determine the concentration of ibuprofen in biological fluids such as human serum or urine. This test can be done by first treating the sample with trifluoroacetic acid (TFA) to convert ibuprofen to its glucuronide conjugate. The glucuronide conjugates are then deproteinized with hydrochloric acid, which converts them into their corresponding carboxylated derivatives. This conversion allows for the separation of ibuprofen from interfering substances using preparative hplc and quantification using mass spectrometry. Toxicity studies have been conducted on bacteria strains and inflammatory bowel
Synonyms:
2-[4-(1-Hydroxy-2-methylpropyl)phenyl]propanoic acid;
UNII-8A1S87ZA87;
1-Hydroxy Ibuprofe;
1-OH-ibuprofen;
1-Hydroxy Ibuprofen;
Ibuprofen Impurity L;
1-Hydroxyibuprofen;
Specification of CAS No.53949-53-4 | 1-Hydroxyibuprofen
|
ITEMS |
SPECIFICATION |
|
CAS |
53949-53-4 |
|
MF |
C13H18O3 |
|
MW |
222.28 |
|
Melting point |
80-85°C |
|
Boiling point |
367.5±22.0 °C(Predicted) |
|
Density |
1.119±0.06 g/cm3(Predicted) |
|
acidity coefficient(pKa) |
4.39±0.10(Predicted) |
Package and transportation of Introduction and application of CAS No.53949-53-4 | 1-Hydroxyibuprofen
Package:0.1g,1g,5g,25g,100g,500g,1kg
Transportation: by courier/ by air/ by sea
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