Introduction and application of CAS 5118-06-9 | Methyl 3-hydroxythiophene-2-carboxylate
Methyl 3-hydroxythiophene-2-carboxylate is an organic compound consisting of a methyl group attached to a thiophene ring. It is a precursor to the drug amiloride, which is used to treat hypertension and edema.
The compound can be formed by the reaction of hydrogen chloride with an alcohol in alkaline conditions. It can also be synthesized from 3-chlorothiophene-2-carboxylic acid and methanol in dilute hydrochloric acid.
In addition, it can be prepared by chlorination of methyltetrahydrothiophene-2-carboxylic acid in the presence of copper(II) oxide as a catalyst. The compound has been decarboxylated at 200°C and then reacted with chloroform under refluxing conditions to produce amiloride.
Synonyms:
methyl 3-hydroxy-thiophene-2-carboxylate;
3-oxy-2-carbomethoxy-thiophene;
3-Hydroxythiophene-2-carboxylic acid methyl ester;
3-Hydroxy-2-thiophenecarboxylic Acid Methyl Ester;
2-methoxycarbonyl-3-hydroxy-thiophene;
2-carbomethoxy-3-hydroxy-thiophene;
Methyl 3-hydroxy-2-thiophenecarboxylate;
Methyl 3-Hydroxythiophene-2-Carboxylate;
Specification of CAS 5118-06-9 | Methyl 3-hydroxythiophene-2-carboxylate
|
ITEMS |
SPECIFICATION |
|
CAS |
5118-06-9 |
|
MF |
C6H6O3S |
|
MW |
158.18 |
|
Boiling point |
107-109°C 13mm |
|
Density |
1.372±0.06 g/cm3(Predicted) |
|
Water solubility
|
Slightly soluble in water. |
|
acidity coefficient(pKa) |
9.47±0.10(Predicted) |
Package and transportation of Introduction and application of CAS 5118-06-9 | Methyl 3-hydroxythiophene-2-carboxylate
Package: 5g,25g,100g,500g,1kg,25kg
Transportation: by courier/ by air/ by sea
Related Articles of CAS 5118-06-9 | Methyl 3-hydroxythiophene-2-carboxylate
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C Corral, MB El‐Ashmawy, J Lissavetzky… - Journal of …, 1987 - Wiley Online Library
The indirect introduction of an azolyl group in position 5 of compound 1 by an easy two‐step
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