CAS:39856-58-1|3-Amino-2-bromopyridine

Introduction and application of CAS:39856-58-1|3-Amino-2-bromopyridine

2-Bromo-3-aminopyridine is a one-pot synthesis of pyrrolo[3,2-b]pyridine/indole via palladium-catalyzed alkynylation-heterocyclization of (amino)bromopyridine/bromoaniline with alkynes. Useful reagents. Preparation of 2-bromo-3-aminopyridine can be obtained from 3-aminopyridine as raw material through NBS bromination. Take 47 grams (0.5 mol) of 3-aminopyridine and dissolve it in 750 ml (15 times the amount) of CH2Cl2. Use dry ice and ethanol to control the temperature -10°C (internal temperature) in a 1-liter three-necked flask, and add 89 grams in batches. (0.5mol) NBS is added in about 15 minutes. After 15 minutes of reaction, the raw material almost disappears. Add water to separate, extract the aqueous phase with dichloromethane, dry the combined organic phases, spin dry, and use dichloromethane/petroleum ether = 1:3 Use the eluent to pass through the column to obtain 25 grams of 2-bromo-3-aminopyridine.

Specification of CAS:39856-58-1|3-Amino-2-bromopyridine

Melting point 76-80°C
Boiling point 292.5±20.0°C(Predicted)
Density 1.710±0.06g/cm3(Predicted)
Storage conditionsKeep in dark place,Sealed in dry,RoomTemperature
Acidity coefficient (pKa)1.72±0.10(Predicted)
Form crystalline powder
Color beige to dark brown

Package of CAS:39856-58-1|3-Amino-2-bromopyridine

25kg/drum

This product is valid for 24 months from the production date when stored in a warm sealed state.

Safety and Transportation

This product should be stored and sealed at room temperature. Customers should carefully read the product treatment, material safety data sheet (MSDS), and labels before use, be familiar with the product's safety information, operating instructions, and environmental impact, and wear appropriate personal protection as required. supplies.

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