Products Description
Introduction and application of CAS:13737-04-7|2-(Trimethylsilyl)pyridine
2-Trimethylsilylpyridine is a pyridine derivative that can be used as an intermediate in organic synthesis. Preparation A solution of 2-chloropyridine (20.7 mL, 217 mmol) and trimethylchlorosilane (28.0 mL, 221 mmol) in THF (100 mL) was added dropwise to rapidly stirring magnesium chips (6.75 g, 281 mmol) in THF (175 ml) mixture. After approximately 10 mL of solution was added, diiodomethane (0.2 mL) was added, followed by iodine particles, followed by isopropylmagnesium chloride (2.0 MTHF solution, 1 mL, 2 mmol). The suspension was then carefully heated to reflux and the remaining chloride solution was added dropwise over 2.75 hours. The reaction was then allowed to cool to room temperature and stirred overnight. Approximately 200 mL of THF was removed by distillation and benzene (125 mL) was added. The suspension was refluxed for 2 hours, then the benzene was decanted off. The process was then repeated by adding more benzene (2x125 mL), refluxing (1 hour each time) and decanting. The combined benzene fractions were concentrated in vacuo and distilled to give 2-trimethylsilylpyridine (2-trimethylsilylpyridine) as a colorless liquid. 6.97g, 46.2mmol, 21%).
Specification of CAS:13737-04-7|2-(Trimethylsilyl)pyridine
Boiling point 47-49°C5mmHg(lit.)
Density 0.9113g/mLat25°C(lit.)
Refractive index n20/D1.489(lit.)
Flash point 126°F
Storage conditionsKeepindarkplace,Inertatmosphere,Room temperature
Transparent liquid
Package of CAS:13737-04-7|2-(Trimethylsilyl)pyridine
25kg/1kg/drum
This product is valid for 24 months from the production date when stored in a warm sealed state.
Safety and Transportation
This product should be stored and sealed at room temperature. Customers should carefully read the product treatment, material safety data sheet (MSDS), and labels before use, be familiar with the product's safety information, operating instructions, and environmental impact, and wear appropriate personal protection as required. supplies.
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