Brief Description
2-(5-Bromothien-2-yl)pyridine (CAS 123784-07-6) is a heteroaromatic compound consisting of a pyridine ring linked to a brominated thiophene ring. It serves as a versatile building block in pharmaceutical and organic synthesis, particularly for constructing conjugated systems, bidentate ligands, and functionalized thiophene derivatives. Available as a crystalline solid with batch-specific COA and SDS support.
Detailed Description
Key Features
Bifunctional Heteroaromatic Scaffold: Combines a pyridine nitrogen (hydrogen-bond acceptor and metal-coordination site) with a bromothiophene moiety (cross-coupling handle), enabling orthogonal functionalization
Cross-Coupling Ready: The C–Br bond on the thiophene ring is suitable for Suzuki, Stille, and Buchwald-Hartwig couplings to introduce diverse aryl, alkyl, or amino substituents
Ligand Precursor: The pyridine–thiophene linkage provides a bidentate coordination environment for transition-metal catalysis and materials chemistry
Crystalline Solid: Defined melting point (87°C) ensures reproducible handling and weighing
Consistent Batch Quality: Each lot accompanied by COA and HPLC purity data for full traceability
Specification Table
| Item | Specification |
|---|---|
| Product Name | 2-(5-Bromothien-2-yl)pyridine |
| Synonyms | 2-(5-Bromo-2-thienyl)pyridine; 2-(5-Bromothiophen-2-yl)pyridine |
| CAS No. | 123784-07-6 |
| Molecular Formula | C9H6BrNS |
| Molecular Weight | 240.12 g/mol |
| Purity | ≥97% (HPLC); 95% available |
| Appearance | Solid |
| Melting Point | 87°C |
| Boiling Point | 301.7°C / 760 mmHg |
| Density | 1.563 g/cm³ |
| Flash Point | 136.2°C |
| Storage | Sealed, cool, dry, well-ventilated place |
| Package Size | 1kg / 5kg / 25kg drum (custom available) |
| Documentation | COA, SDS available upon request |
Product Details
2-(5-Bromothien-2-yl)pyridine is a heteroaryl bromide featuring a pyridine ring at the 2-position of a thiophene ring that bears a bromine atom at the 5-position. The molecule is a crystalline solid at room temperature with a melting point of approximately 87°C . The compound is insoluble in water but soluble in common organic solvents. The bromine atom serves as a reactive handle for transition-metal-catalyzed cross-coupling reactions, while the pyridine nitrogen provides coordination capacity and hydrogen-bond acceptor functionality. The compound is not listed on major chemical inventories including TSCA, EINECS, and China IECSC .
Application Areas
Pharmaceutical Synthesis: Intermediate for bioactive heteroaromatic compounds and drug candidate development
Organic Materials: Building block for conjugated polymers, organic semiconductors, and organic light-emitting diodes (OLEDs)
Ligand Synthesis: Precursor for bidentate pyridine–thiophene ligands in transition-metal catalysis
Cross-Coupling Chemistry: Substrate for Suzuki, Stille, and other palladium-catalyzed transformations to access functionalized thiophene derivatives
Customization
Purity Grades: ≥95% and ≥97% available
Packaging: Custom package sizes from kilograms to multi-ton quantities
Documentation Packages: Batch-specific COA and SDS provided per lot
Packing & Service
Packing: Standard 25 kg fiber drum or plastic drum for bulk orders. Custom labeling available.
Lead Time: In-stock items ship within 5–7 business days. Bulk orders quoted upon request.
Quality Support: Every shipment includes a batch-specific COA. Technical support available for handling and storage recommendations.
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