Introduction and application of CAS No.90-99-3 | Chlorodiphenylmethane
Chlorodiphenylmethane is a chemical reagent used in purification processes including the purification diphenhydramine hydrochloride. Also used in the synthesis of novel benzhydrylpiperazine carboxamide and thioamide derivatives.
Chlorodiphenylmethane is a member of the class of aliphatic hydrocarbons. It is an inhibitor of inflammatory bowel disease and has been shown to be effective in patients with ulcerative colitis. Chlorodiphenylmethane can inhibit inflammatory bowel disease through a number of different mechanisms, including inhibition of the production of cytokines, such as IL-1β and TNF-α, by inhibiting the activation of NF-κB. The mechanism for this inhibition is not fully understood but may involve nucleophilic attack on the carbonyl group on the aromatic ring, which leads to hydrogen fluoride or hydroxyl groups being released from the molecule.
Synonyms:
DIPHENYLCHLOROMETHANE;
Methane,chlorodiphenyl;
1,1-DIPHENYLCHLOROMETHANE;
Benzene, 1,1'-(chloromethylene)bis-;
Benzhydryl chloride;
DIPHENYLMETHYL CHLORIDE;
1-chloro-1,1-diphenylmethane;
diphenyl-1-chloromethane;
Specification of CAS No.90-99-3 | Chlorodiphenylmethane
|
ITEMS |
SPECIFICATION |
|
CAS |
90-99-3 |
|
MF |
C13H11Cl |
|
MW |
202.68 |
|
Melting point |
15-17 °C(lit.) |
|
Boiling Point |
140 °C3 mm Hg(lit.) |
|
Density |
1.14 g/mL at 25 °C(lit.) |
|
Refractive Index |
n20/D 1.595(lit.) |
Package and transportation of Introduction and application of CAS No.90-99-3 | Chlorodiphenylmethane
Package:0.1g,1g,5g,25g,100g,500g,1kg
Transportation: by courier/ by air/ by sea


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JH Son, SR Tamang, JI Fostvedt… - Organometallics, 2017 - ACS Publications
… The zwitterion also formed upon addition of methylene chloride or
chlorodiphenylmethane. … In particular, diphenyl carbene forms from …
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