CAS: 309-88-6 | N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine

Introduction and application of CAS: 309-88-6 | N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine

Overview N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine can be used to prepare florfenicol, also known as D(+)-threo-1-p Methyl sulfonyl phenyl-2-dichloroacetamido-3-fluoropropanol is an animal-specific broad-spectrum antibiotic developed by the American Schering-Plough Company in the 1970s. Benicol's antibacterial activity against sensitive bacteria is similar to that of chloramphenicol and thiamphenicol, but it still has strong antibacterial activity against chloramphenicol and thiamphenicol-resistant bacteria, such as Klebsiella pneumoniae and hemolytica Pasteurella, Actinomyces pleuropneumoniae and Salmonella typhi, etc. Since chloramphenicol has serious adverse reactions causing aplastic anemia, its use in food animals has been banned in many countries. Therefore, florfenicol has broad application prospects in the prevention and treatment of animal diseases.
Preparation of N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine is as follows: Take 600-700 parts of dichloromethane, add 65-85 parts of diethylamine, and cool down. to ‑5℃～‑25℃, pass in 110 parts to 165 parts of hexafluoropropylene, react for 1 hour after passing through, and obtain the fluorination reagent for later use; the added amount of diethylamine is preferably 75 to 80 parts, and the amount of hexafluoropropylene is The added amount is preferably 160 to 165 parts. Used for fluorination reactions.

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