CAS:136516-64-8 | Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)

Introduction of CAS:136516-64-8 | Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)

The molecular structure of benzaldehydes can be quite complex, with intramolecular hydrogen bonding and planar configurations being common features. For example, 2,4-Dihydroxybenzaldehyde forms sheets with intermolecular hydrogen bonds, and its molecules are characterized by an intramolecular hydrogen bond . The presence of substituents like fluorine in 2,4-Difluoro-6-hydroxybenzaldehyde would likely influence its molecular geometry and intermolecular interactions, potentially leading to unique structural motifs.

Specification of CAS:136516-64-8 | Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)

Research Application of CAS:136516-64-8 | Benzaldehyde, 2,4-difluoro-6-hydroxy- (9CI)

Reaction and Catalysis

2-Hydroxybenzaldehydes, closely related to 2,4-Difluoro-6-hydroxybenzaldehyde, efficiently react with alkynes, alkenes, or allenes, facilitated by a rhodium-based catalyst system. This reaction involves the cleavage of the aldehyde C-H bond, leading to the formation of 2-alkenoylphenols (Kokubo et al., 1999).

Organic Synthesis

Electron-rich benzaldehyde derivatives, such as 2,4-dihydroxybenzaldehyde, are used as linkers for solid-phase organic synthesis. They undergo reductive amination and further derivatization to form various amide compounds (Swayze, 1997).

Cu(OAc)2 catalyzes the oxyfunctionalization of 4-hydroxybenzaldehydes and derivatives, converting them into various aromatic carbonyl compounds. This process is significant for pharmaceutical applications due to the importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones (Jiang et al., 2014).

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