CAS:124011-52-5 | 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT

Introduction of CAS:124011-52-5 | 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT

MPEG-DSPE, or MPEG-Drug Substance Processing and Evaluation, is a technology developed by the Moving Picture Experts Group (MPEG) that enables the evaluation of drug substances. This technology has been widely used in the pharmaceutical industry for the evaluation of drug substances, as well as in laboratory experiments. It is a powerful tool that can be used to assess the quality and safety of drug substances and to provide valuable information for drug development.

Specification of CAS:124011-52-5 | 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT

Research Application of CAS:124011-52-5 | 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT

MPEG-DSPE in Nanoparticle Imaging and Drug Delivery

MPEG-DSPE has been utilized in the development of near-infrared fluorophores for skeletal system imaging. A study highlighted the use of DSPE-mPEG encapsulated rare earth doped nanoparticles (RENPs@DSPE-mPEG) demonstrating an inherent affinity to bone without targeting ligands. This approach offers a non-invasive strategy for skeletal system mapping and bone disease diagnoses, with potential in immunotherapy and cancer-targeted nanoparticles (He et al., 2019).

Impact on Liposomal Drug Formulations

DSPE-mPEG, a family of amphiphilic lipopolymers, plays a significant role in formulating injectable, long-circulating nanoparticulate drug formulations. Research has shown its effectiveness in PEGylation of lipidic nonlamellar liquid crystalline particles, which are used in developing cubosomes and hexosomes for drug and imaging probe delivery. The incorporation of DSPE-mPEG into these formulations impacts their morphology and internal nanostructure, enhancing their potential in drug delivery systems (Nilsson et al., 2014).

Reversible Attachment of Polyethylene Glycol

The reversible attachment of methoxypoly(ethylene glycol) (mPEG) to amino-containing substrates using DSPE has been explored. This strategy, involving the formation of a benzyl carbamate linkage substituted with a disulfide, allows the creation of lipopolymers capable of losing their polymer coating under specific conditions. This approach is significant in the context of drug delivery, where controlled release and targeting are crucial (Zalipsky et al., 1999).

Cell Surface Engineering

DSPE-mPEG has been investigated in the context of cell surface engineering. It has been used to modify the cell surface, impacting various cellular behaviors such as viability, growth, proliferation, and adhesion. This study demonstrated that DSPE-mPEG modification highly affects cell adherence, providing insights into the application of cell surface engineering in biomedicine (Cai et al., 2022).

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