(2-sulfanylethyl)phosphonic Acid ｜ CAS 43064-23-9 ｜Alfa Chemical

Bifunctional Structure

Thiol (-SH) and phosphonic acid (-PO(OH)₂) groups on a short ethyl backbone enable versatile surface chemistry.

Strong Metal Affinity

Binds strongly to metal oxides (HfO₂, Al₂O₃, TiO₂) and noble metals (Au, Ag) via M–O–P bonds.

High Purity

≥95% purity (customizable). Batch-specific COA and SDS provided with every shipment.

China Manufacturer

Factory-direct pricing, in-stock availability, and fast worldwide delivery.

Self-Assembled Monolayers (SAMs)

Challenge: Forming stable, well-ordered monolayers on metal oxide and noble metal surfaces requires a molecule that can anchor through multiple binding modes.

Solution: MEPA's phosphonic acid group anchors to metal oxides (HfO₂, Al₂O₃, TiO₂, steel), while its thiol group binds to gold and silver surfaces.

Result: Uniform, stable SAMs suitable for sensor surfaces, interface engineering, and nanomaterial functionalization.

Metal Ion Chelation

Challenge: Heavy metal recovery and wastewater treatment require chelating agents that remain stable under harsh conditions.

Solution: The M–O–P bond formed by phosphonic acids is highly stable under acidic and high-temperature conditions. The thiol group provides a regenerable scavenging site for soft metal ions.

Result: Effective chelation for heavy metal recovery, wastewater treatment, and catalyst preparation.

Organic Synthesis Intermediates

Challenge: Building phosphorus-sulfur compounds often requires a single precursor that can introduce both elements in a controlled manner.

Solution: MEPA provides both phosphorus and sulfur in one molecule, serving as a versatile building block for downstream synthesis.

Result: Used in the synthesis of pharmaceutical and agrochemical intermediates, and in the preparation of functional phosphorus-sulfur materials.

Advanced Material Interfaces

Challenge: Nanomaterials and sensor surfaces require precise chemical functionalization to control interfacial properties.

Solution: MEPA can functionalize gold nanoparticles, ZnO nanowires, and other inorganic surfaces through its bifunctional binding chemistry.

Result: Enables preparation of functional hybrid materials and engineered interfaces for sensing and catalysis.

🏭 Production Capacity

Manufactured in Zhengzhou, China. Standard production capacity supports gram-scale to kilogram-scale orders.

📋 Batch Traceability

Each batch is tested for purity, appearance, and functional group integrity. Batch-specific COA is available on request.

Packaging

1g / 5g / 10g (Teflon-coated inside; custom available)

Lead Time

3–7 business days from stock

Shipping

DHL / FedEx (samples); Air / Sea freight (bulk)

In-Stock Availability

Ready to ship within 3–7 business days

Flexible Order Volumes

Gram-scale samples to kilogram-scale orders

China Manufacturer Direct

Competitive pricing with full COA/SDS traceability

MEPA contains a thiol group, which can slowly oxidize to disulfide in the presence of oxygen. Recommended storage: sealed container, protected from light, in a cool dry place. For long-term storage, keep under nitrogen or argon. Avoid exposure to strong oxidizers.

MEPA is soluble in water, methanol, and ethanol. It is slightly soluble in acetone and practically insoluble in non-polar solvents like hexane or toluene. For SAM preparation, dilute ethanol or aqueous ethanol (10–50%) is commonly used.

MEPA forms stable monolayers on metal oxides (HfO₂, Al₂O₃, TiO₂, ITO, stainless steel) through its phosphonic acid group, and on noble metals (Au, Ag) through its thiol group. It is particularly useful when a single molecule must anchor to two different substrate types.

The thiol group can react with epoxy groups under amine catalysis, making MEPA useful as an adhesion promoter or crosslinker in hybrid systems. The phosphonic acid group can also participate in silane condensation. Compatibility depends on the specific formulation - contact our technical team for guidance.

We offer gram-scale samples (1g–10g) for R&D and kilogram-scale orders for production. Custom purity and custom packaging are available. Contact us with your required quantity and specification for a quote.

Yes. Every shipment includes a batch-specific COA and SDS. If you need a specific batch or historical lot documentation, contact us and we will locate it.