CAS No.609-08-5 | Diethyl Methylmalonate

Introduction and application of CAS No.609-08-5 | Diethyl methylmalonate

Diethyl methylmalonate is an organic compound with the chemical formula CH3COCH2COOC2H5. It is a sodium salt of diethyl methylmalonate, which is a nitrite ion donor. Diethyl methylmalonate has been used to catalyze the palladium-catalyzed coupling of alkanoic acids and methylmalonic acid in the presence of triethylamine. This reaction converts the alkanoic acid into an ester and methylmalonic acid into an alcohol. The reaction mechanism for this process involves a transfer reaction from diethyl methylmalonate to the alkanoic acid followed by nucleophilic substitution at carbon atom 2 of the alkanocarboxylic acid by methyll malonyl chloride.

Diethyl methylmalonate is readily used as a moderately bulky nucleophile in organic synthesis. Diethyl methylmalonate is also used as a reagent to synthesize 7-alkylaminopyrazolo[1,5-a]pyrimidines, compounds that have antifungal properties.

Synonyms:

Propanedioic acid, methyl-, diethyl ester;

diethyl 2-methylpropanedioate;

Specification of CAS No.609-08-5 | Diethyl methylmalonate

Package and transportation of Introduction and application of CAS No.609-08-5 | Diethyl methylmalonate

Package:0.1g,1g,5g,25g,100g,500g,1kg

Transportation: by courier/ by air/ by sea

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