CAS:104-53-0 | Phenylpropyl Aldehyde

CAS:104-53-0 | Phenylpropyl Aldehyde

3-Phenylpropanal, also known as hydrocinnamaldehyde or benzenepropanal, belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene. 3-Phenylpropanal exists as a solid and is considered to be practically insoluble (in water) and relatively neutral. Within the cell, 3-phenylpropanal is primarily located in the cytoplasm. 3-Phenylpropanal is a balsam, chocolate, and cinnamon tasting compound that can be found in a number of food items such as fruits, alcoholic beverages, chinese cinnamon, and herbs and spices. This makes 3-phenylpropanal a potential biomarker for the consumption of these food products.

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Henan Alfa Chemical Co., Ltd, was established in China decades ago with the goal of providing high-quality chemicals to our customers. Over the years, we have consistently strived to uphold our reputation as a reliable and trustworthy chemical supplier in the market.In the early days, we started by supplying basic chemicals to small businesses. However, as our reputation grew, so did our customer base and the variety of chemicals we supplied. We are now proud to offer a wide range of chemicals including reagents, material chemicals and biological chemicals tailored to meet the needs of various industries & research fields.

 

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What is Phenylpropyl Aldehyde

3-Phenylpropanal, also known as hydrocinnamaldehyde or benzenepropanal, belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene. 3-Phenylpropanal exists as a solid and is considered to be practically insoluble (in water) and relatively neutral. Within the cell, 3-phenylpropanal is primarily located in the cytoplasm. 3-Phenylpropanal is a balsam, chocolate, and cinnamon tasting compound that can be found in a number of food items such as fruits, alcoholic beverages, chinese cinnamon, and herbs and spices. This makes 3-phenylpropanal a potential biomarker for the consumption of these food products.

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Benefits of Phenylpropyl Aldehyde
 
 

Effective anti-ulcer

Phenylpropionaldehyde is one of the important pharmaceutical raw materials and is commonly used in external medicines and synthetic drugs. It can promote blood circulation, warm the skin, and tighten skin tissue. It is effective in softening and removing skin scars and fibroids, has an antithrombin effect, and has sedative, analgesic, antipyretic, and anticonvulsant effects. It can also effectively fight ulcers and promote gastrointestinal motility.

 
 
 

Can inhibit the occurrence of tumors

It can also inhibit the occurrence of tumors and has anti-cancer functions such as anti-mutagenic and anti-radiation effects. Its own blood vessel dilation and antihypertensive effects have a significant antihypertensive effect on adrenocortical hypertension. In industry, it can be used as chromogen, experimental reagent, insecticide, mosquito repellent, preservative, etc. It has a good fragrance-holding effect and is used as a fragrance raw material in perfumery to make the aroma of the main spice more fragrant and stable. It is often used as a fixative.

 
 
 

Disinfection function

Phenylpropionaldehyde is not affected by the pH value and has strong sterilization and disinfection functions for acidic or alkaline substances. It is commonly used as a fresh-keeping, antiseptic and antifungal agent. Also a good flavoring oil. It has inhibitory effects on more than 20 kinds of fungi such as Escherichia coli, Staphylococcus aureus, Shigella dysenteriae, typhoid fever, pneumococci, and Salmonella enteritidis.

 

 

What are the Applications of Phenylpropyl Aldehyde

Flavor and Fragrance Industry
One of the primary uses of phenylpropyl aldehyde is in the formulation of perfumes and flavorings. Its warm, sweet, balsamic odor makes it a popular choice for creating scents that mimic natural essential oils.It is often found in products like colognes, soaps, detergents, and air fresheners.In the food industry, it is used to add a cinnamon-like taste to baked goods, beverages, and confectionery.

 

Chemical Synthesis
Phenylpropyl aldehyde is a precursor in the synthesis of various chemicals and can be used to produce more complex compounds, such as cinnamyl alcohol upon reduction.It serves as a starting material for the production of certain pharmaceuticals, flavors, and fragrances.

 

Pharmaceutical Applications
Due to its structural similarity to naturally occurring compounds, phenylpropyl aldehyde can be employed in the synthesis of potential drug candidates with biological activity.It may play a role in the development of medications that require specific aromatic groups for interaction with biological targets.

 

Selective Hydrogenation In Perfume And Pharmaceutical Manufacturing
Hydrocinnamaldehyde is produced through selective hydrogenation of cinnamaldehyde. Studies like Li et al. (2018) show that incorporating silver into palladium-based catalysts significantly improves catalytic activity and selectivity for hydrocinnamaldehyde production, essential for perfumes and pharmaceuticals manufacturing (Li et al., 2018).

 

Gas Phase Transfer Hydrogenation
Research by S. K et al. (2020) demonstrated that the conversion of cinnamaldehyde to hydrocinnamaldehyde via transfer hydrogenation catalyzed by supported Cu catalysts depends on the active Cu metal surface area and the nature of support material (S. K et al., 2020).

 

 
 
Synthesis Method of Phenylpropionaldehyde
01.

Alkylation reaction of phenylpropionaldehyde

Phenylpropanaldehyde undergoes a hydrocarbonization reaction under the action of the catalyst aluminum trichloride to generate by-products such as cumene and polyalkyl compounds. The reaction liquid is washed with water and alkali, then enters the benzene removal tower to remove benzene, and finally enters the cumene tower for evaporation.

02.

Oxidation

Phenylpropanaldehyde is oxidized with air and oxygen in the oxidation tower to generate cumene hydroperoxide. The oxidation process needs to be carried out at specific temperatures and pressures to ensure the generation and stability of cumene hydroperoxide. 123

03.

Break down

Phenylpropionaldehyde decomposes under the action of sulfuric acid catalyst to produce phenol and acetone. This step is the core of the entire process and requires precise control of reaction conditions to ensure product quality and purity. 1234

04.

Distillation and purification

The mixture of phenylpropionaldehyde and acetone undergoes a distillation and purification process to remove impurities and unreacted raw materials, and finally obtain high-purity phenol and acetone products. During the production process, some by-products such as α-methylstyrene are also produced and acetophenone, these also require appropriate treatment and recycling.

 

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Reduction Reaction of Phenylpropanal

The reduction reaction of phenylpropanal refers to the reaction in which phenylpropanal receives electrons and is reduced to other compounds Response process. Phenylpropanal can be reduced to phenylpropanol through reducing agents such as sodium bisulfite and hydrogen gas.

Sodium bisulfite reduction reaction:
C6H5CH2CHO+NaHSO3+H+→ C6H5CH2CH2OH+NaHSO4

Hydrogen reduction reaction:
C6H5CH2CHO+H2 → C6H5CH2CH2OH
In the reduction reaction of phenylpropanal, the carbon atom on the carboxyl group gains electrons and is reduced to formyl The oxygen atom on the formate group loses electrons, forming a formyl group.

The Oxidation Reaction of Phenylpropanal

The oxidation reaction of phenylpropanal refers to the reaction in which phenylpropanal loses electrons and oxidizes into other compounds Response process. Benzaldehyde can be oxidized by oxidants such as oxygen and hydrogen peroxide during the oxidation reaction.

Oxygen oxidation reaction:
C6H5CH2CHO+1/2O2 → C6H5CH2COOH

Hydrogen peroxide oxidation reaction:
C6H5CH2CHO+H2O2 → C6H5CH2COOH+H2O

During the oxidation reaction of phenylpropanal, the carbon atom on the formyl group loses electrons, forming formic acid The carbon atom on the benzene ring receives electrons from the oxygen atom, forming a carboxyl group. This oxidation reaction It can also be regarded as the oxidation-reduction reaction of phenylpropanal.

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Phenylpropionaldehyde Storage Conditions

Cool: Should be stored in a cool place to avoid direct sunlight and high temperatures.
Ventilation: Keep the warehouse well ventilated to facilitate air circulation.
Sealing: Keep containers sealed to prevent substances from evaporating or leaking.
Keep away from fire and heat sources: Keep away from fire and heat sources to reduce the risk of fire.
Avoid contact with oxidants, strong alkali and air: It should be stored separately from oxidants, strong alkali and air to avoid chemical reactions that may lead to deterioration or danger.
Storage temperature: The recommended storage temperature is 4 ºC, but 2-8 ºC is also recommended, so you can choose the appropriate temperature range according to the specific situation.

Research Progress on The Redox Potential of Phenylpropanal

Phenylpropanal, as an important organic compound, has also been studied in the study of redox potential Widespread attention. Many studies have shown that the redox potential of phenylpropanal is related to its structure and environment The factors are closely related.

Structural factors
The structure of phenylpropanal can be achieved by changing the substitution position of functional groups on the benzene ring The properties of substituents are used to regulate their redox potential. For example, the methyl substitution of phenylpropanalThe oxidation-reduction potential is easier than that of phenylpropanal itself, while phenylpropanal with electron donors as substituents The oxidation-reduction potential is easier for phenylpropanal with electron acceptors as the substituent.

Environmental factors
PH value, temperature, and other environmental factors can also affect the redox electricity of phenylpropanal Potential has an impact. Generally speaking, lower pH values and higher temperatures can cause the oxidation of phenylpropanalReducing the potential becomes easier.

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Henan Alfa Chemical Co., Ltd, was established in China decades ago with the goal of providing high-quality chemicals to our customers. Over the years, we have consistently strived to uphold our reputation as a reliable and trustworthy chemical supplier in the market.In the early days, we started by supplying basic chemicals to small businesses. However, as our reputation grew, so did our customer base and the variety of chemicals we supplied. We are now proud to offer a wide range of chemicals including reagents, material chemicals and biological chemicals tailored to meet the needs of various industries & research fields.

 

 
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FAQ
 
 

Q: What is the CAS number of phenyl propyl aldehyde?

A: 3-Phenylpropanal (cas# 104-53-0) is a compound useful in organic synthesis.

Q: What is difference between phenol and phenyl?

A: The main difference between phenol and phenyl is that phenol is composed of an oxygen atom, whereas phenyl does not have oxygen atoms bound to it. The difference between Phenyl and Phenol: Phenyl is a benzene ring, that lacks a hydrogen atom and is an unstable compound. It is a highly reactive compound.

Q: Is aldehyde and acetaldehyde same?

A: Acetaldehyde (ethanal) is an aldehyde that is highly reactive and toxic. Acetaldehyde causes damage at the cellular and genomic levels. The sheer number of enzymes involved in the metabolism and detoxication of acetaldehyde and other aldehyde species is a testament to the impact of its reactivity.

Q: What is phenyl acetaldehyde used for?

A: Phenylacetaldehyde is an organic compound used in the synthesis of fragrances and polymers. Phenylacetaldehyde is an aldehyde that consists of acetaldehyde bearing a phenyl substituent; the parent member of the phenylacetaldehyde class of compounds.

Q: How many compounds are in CAS?

A: CAS REGISTRY contains more than 127 million unique organic and inorganic chemical substances, such as alloys, coordination compounds, minerals, mixtures, polymers and salts, and more than 66 million sequences-more than any other database of its kind.Phenyl isocyanate for synthesis. CAS 103-71-9, EC Number 203-137-6, chemical formula C₆H₅NCO.

Q: Why is phenol no longer used?

A: Because of its irritant and corrosive properties and potential systemic toxicity, at present phenol is not commonly used as an antiseptic, except to cauterize infected areas-eg, the infected umbilicus of neonates.Phenol was discovered in 1834 by Friedlieb Ferdinand Runge, who extracted it (in impure form) from coal tar. Runge called phenol "Karbolsäure" (coal-oil-acid, carbolic acid).

Q: Is phenyl just benzene?

A: The phenyl group is closely related to benzene and can be viewed as a benzene ring, minus a hydrogen, which may be replaced by some other element or compound to serve as a functional group.Acetaldehyde is an important aldehyde which when reacts with phenylhydrazine gives aldehyde phenylhydrazine. Phenylhydrazine is used to convert various sugar mixtures to phenylhydrazones.

Q: Why is acetaldehyde bad?

A: Some of the acetaldehyde enters your blood, damaging your membranes and possibly causing scar tissue. It also leads to a hangover, and can result in a faster heartbeat, a headache or an upset stomach. The brain is most affected by acetaldehyde poisoning. It causes problems with brain activity and can impair memory.

Q: What is 3 phenyl propyl alcohol used for?

A: Application. 3-Phenyl-1-propanol was used to study the hydrogenation of trans-cinnamaldehyde using water-soluble organometallic complexes[2]. It was used as starting reagent during the enantioselective synthesis of (S)- and (R)-dapoxetine[3].It is a colorless liquid with a mild gardenia-hyacinth scent. Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Phenylethanol is an aromatic alcohol, it has the role of mouse metabolite.

Q: What is the name of phenyl with alcohol?

A: 2-phenylethanol is a primary alcohol that is ethanol substituted by a phenyl group at position 2. It has a role as a fragrance, a Saccharomyces cerevisiae metabolite, a plant metabolite, an Aspergillus metabolite and a plant growth retardant. It is a primary alcohol and a member of benzenes.

Q: What does phenyl look like?

A: Phenyls are aromatic rings with a formula C 6 H 5 and are classified in the category of alkyls. The symbol Ph is used to designate phenyls in chemical formulas and names of organic compounds. Phenyl groups are derived from benzene molecules and have a ring structure.Most of the ethanol in the body is broken down in the liver by an enzyme called alcohol dehydrogenase (ADH), which transforms ethanol into a toxic compound called acetaldehyde (CH3CHO), a known carcinogen.

Q: Can an alcohol be an aldehyde?

A: Primary alcohols can be oxidized to either aldehydes or carboxylic acids, depending on the reaction conditions. In the case of the formation of carboxylic acids, the alcohol is first oxidized to an aldehyde, which is then oxidized further to the acid.

Q: What type of alcohol is aldehyde?

A: An alcohol with its –OH group bonded to a carbon atom that is bonded to no or one other carbon atom will form an aldehyde.Chemical Abstracts Service (CAS) Number: A unique accession number assigned by the Chemical Abstracts Service, a division of the American Chemical Society.

Q: What does a CAS number tell you?

A: A CAS Registry Number itself has no inherent chemical significance but provides an unambiguous way to identify a chemical substance or molecular structure when there are many possible systematic, generic, proprietary or trivial names.Phenyl Isocyanate is a liquid with an irritating odor. It is used as a laboratory reagent and to make other chemicals.

Q: What is phenyl Isocyanide?

A: Phenyl isocyanate is an organic compound typically abbreviated PhNCO. The molecule consists of a phenyl ring attached to the isocyanate functional group. It is a colourless liquid that reacts with water. Phenyl isocyanate has a strong odor and tearing vapours, therefore it has to be handled with care.

Q: What is more stronger than phenol?

A: Hence, benzoic acid is a stronger acid than phenol. Hence phenol, being very weak acids do not react with weak bases such as sodium hydrogen carbonate. However, benzoic acid being a strong acid, reacts with sodium hydrogen carbonate to give effervescence of carbon dioxide gas.Phenol was included on LOUS due to high tonnage use in Denmark and because the substance of its harmonised classification as acutely toxic, dangerous by prolonged exposure and mutagenic in category 2.

Q: Does phenol expire?

A: It is stable over time, and although it may develop a slight pink colour on exposure to light or air, this doesn't affect its potency. There is therefore no rationale for giving an expiry date for liquefied phenol, and as such, liquefied phenol solutions do not have one.Phenol is used in many industries. It's used for medicine as a slimicide, antiseptic, and disinfectant and to manufacture a number of products. Some examples of workers at risk of being exposed to phenol include the following: Workers in the petroleum industry.

Q: Why is phenol not called alcohol?

A: Compounds in which an OH group is attached directly to an aromatic ring are designated ArOH and called phenols. Phenols differ from alcohols in that they are slightly acidic in water. They react with aqueous sodium hydroxide (NaOH) to form salts.The phenyl group is based simply on benzene, with one H removed. The benzyl group is based on methylbenzene (toluene), with one H removed from the methyl group.

Q: What does phenol smell like?

A: Phenol has a distinct odor that is sickeningly sweet and tarry. You can taste and smell phenol at levels lower than those that are associated with harmful effects. Phenol evaporates more slowly than water, and a moderate amount can form a solution with water. Phenol can catch fire.Acetaldehyde is removed from the body primarily by oxidation to acetate via a number of NAD-linked aldehyde dehydrogenase (ALDH) enzymes. There are nineteen known ALDHs in humans, but only a few of them appear to be involved in acetaldehyde oxidation.

Q: What is difference between phenol and phenyl?

A: The main difference between phenol and phenyl is that phenol is composed of an oxygen atom, whereas phenyl does not have oxygen atoms bound to it. The difference between Phenyl and Phenol: Phenyl is a benzene ring, that lacks a hydrogen atom and is an unstable compound. It is a highly reactive compound.

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