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CAS No.850568-62-6 | 5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID

CAS No.850568-62-6 | 5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID

Name:5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID
CAS No.850568-62-6
MF:C20H22BNO5
MW:367.2
Purity:97%
Package: 5g,25g,100g,500g,1kg,25kg
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Product Introduction

Introduction and application of CAS No.850568-62-6 | 5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID

 

5-Benzyloxy-1H-indole-2-boronic acid, N-BOC protected is a potent and selective inhibitor of aurora kinase A (AuroraA) with IC50 of about 20 nM. AurorA is a serine/threonine kinase that regulates cell cycle progression, transcription, DNA repair, and other cellular processes.

 

Synonyms:

[1-[(2-methylpropan-2-yl)oxycarbonyl]-5-phenylmethoxyindol-2-yl]boronic acid;

5-Benzyloxy-1H-indole-2-boronic acid, N-BOC protected;

5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID;

5-Benzyloxyindole-2-boronic acid,N-BOC protected;

2-borono-5-benzyloxy-indole-1-carboxylic acid tert-butyl ester;

1-tert-butyloxycarbonyl-5-benzyloxy-indole-2-boronic acid;

1-boc-indole-5-benzyloxy-2-boronic acid;

5-Benzyloxy-1H-indole-2-boronic acid,N-BOC protected;

 

Specification of CAS No.850568-62-6 | 5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID

ITEMS

SPECIFICATION

CAS

850568-62-6

MF

C20H22BNO5

MW

367.2

Melting point

106-110ºC

Boiling point

564.7±60.0 °C(Predicted)

Density

1.17±0.1 g/cm3(Predicted)

acidity coefficient(pKa)

7.97±0.30(Predicted)

Storage

2-8°C

 

Package and transportation of Introduction and application of CAS No.850568-62-6 | 5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID

Package:0.1g,1g,5g,25g,100g,500g,1kg

Transportation: by courier/ by air/ by sea

 

product-696-396

product-706-367

 

Related Articles of CAS No.850568-62-6 | 5-BENZYLOXY-1-BOC-INDOLE-2-BORONIC ACID

7-[1H-Indol-2-yl]-2, 3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity

TV Hughes, SL Emanuel, HR O'Grady… - Bioorganic & medicinal …, 2008 - Elsevier

… -indole-2-boronic acid afforded 6 in good yield when Pd(dppf)Cl 2 was used as the catalyst.

Similarly, coupling of 2 with 5-benzyloxy-1-Boc-indole-2-boronic acid afforded 7. Removal of …

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