Introduction and application of CAS:931-49-7 | 1-ETHYNYLCYCLOHEXENE
1-Ethynyl-cyclohexane is an organic intermediate, and there are reports in the literature that it can be used to prepare (E)-2,2-difluoro-1-phenyl-4-cyclohexenyl-3-ene-4 -Iodo-1-one and 4-phenoxyquinolino N-sulfonymidine compounds.
Application examples:
1-Ethynyl-cyclohexane can be used to prepare 4-phenoxyquinolino N-sulfonymidine compounds with the following structure. Such compounds can serve as tyrosine kinase inhibitors, especially c-Met inhibitors. c-Met is highly expressed in most solid tumors and some sarcomas and is closely related to poor prognosis, such as lung cancer, breast cancer, colon cancer, prostate cancer, liver cancer, gastric cancer, and glioma. Furthermore, patients with high expression levels of HGF/c-Met are more resistant to chemotherapy and radiotherapy. In addition to abnormal expression of HGF/c-Met, c-Met can also be activated through gene mutations and gene amplification in cancer patients.
Specification of CAS:931-49-7 | 1-ETHYNYLCYCLOHEXENE
| Item | Specification |
Boiling point: 148-151 °C(lit.)
Density: 0.903 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.496(lit.)
Flash point: 85°F
Storage conditions: 2-8°C
Form: clear liquid
Color: colorless
Package and transportation of CAS:931-49-7 | 1-ETHYNYLCYCLOHEXENE
Transportation: by courier/ by air/ by sea.
Related articles of CAS:931-49-7 | 1-ETHYNYLCYCLOHEXENE
Polymerization of 1‐ethynylcyclohexene by tungsten and molybdenum‐based catalysts
YS Gal, B Jung, JH Kim, WC Lee… - Journal of Polymer …, 1995 - Wiley Online Library
Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base–zinc complex
Q Wang, B Zhang, G Hu, C Chen, Q Zhao… - Organic & Biomolecular …, 2007 - pubs.rsc.org
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