CAS:9002-04-4 | Thrombin

Introduction and application of CAS:9002-04-4 | Thrombin

Thrombin is a protease that hydrolyzes fibrinogen into fibrin. It is composed of 308 amino acid residues and is a double-chain molecule, containing A chain and B chain. The two chains are connected by a disulfide bond. Among them, A chain Contains 49 amino acid residues, also known as light chain. The B chain consists of 259 amino acid residues, also known as heavy chain. This product exists in animal blood, usually in the form of inactive zymogen, and can directly act on blood coagulation. In the final step of the process, fibrinogen is turned into fibrin, which accelerates blood coagulation and quickly stops bleeding; it can activate coagulation factor VIII, convert soluble fibrin into insoluble fibrin to form a clot, and achieve hemostasis; it can Enhance the activity of coagulation factors VIII and V, with the participation of calcium and phospholipids, promote thrombin factor It can promote the mitosis of epithelial cells and shorten the wound healing time by 30% to 50%; therefore, it is often used to stop bleeding in small blood vessels, capillaries and solid organs that are difficult to stop bleeding. It can also be used in trauma, surgery, stomatology, Bleeding in otolaryngology, urology, obstetrics and gynecology, and gastrointestinal tract.

Specification of CAS:9002-04-4 | Thrombin

Melting point: 47.7 °C
Storage conditions: -20°C
Solubility: H2O: 1 mL/bottle clear to slightly turbid colorless solution
Form: powder
color: White

Package and transportation of CAS:9002-04-4 | Thrombin

Transportation: by courier/ by air/ by sea.

Related articles of CAS:9002-04-4 | Thrombin

What is all that thrombin for?
KG Mann, K Brummel, S Butenas - Journal of Thrombosis and Haemostasis, 2003 - Elsevier

Directing thrombin
DA Lane, H Philippou, JA Huntington - Blood, 2005 - ashpublications.org

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