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Introduction of CAS:875-97-8 | 2-[(5S)-2,4-dioxothiazolidin-5-yl]acetate
The physical and chemical properties of these derivatives, such as lipophilicity, are important for their biological efficacy and drug-likeness. Techniques like reversed-phase high-performance liquid chromatography (RP-HPLC) have been employed to analyze the lipophilicity of rhodanine-3-acetic acid derivatives . The capacity factor (k) obtained from RP-HPLC and the calculated log P values provide valuable information on the hydrophobic properties of these compounds, which are critical for their interaction with biological membranes and targets.
Specification of CAS:875-97-8 | 2-[(5S)-2,4-dioxothiazolidin-5-yl]acetate
|
ITEMS |
SPECIFICATION |
|
Melt point |
164-167 °C |
|
Density |
1.509±0.06 g/cm3(Predicted) |
|
Boiling point |
489.3±18.0 °C(Predicted) |
|
Density |
1.600±0.06 g/cm3(Predicted) |
|
Acidity coefficient (pKa) |
3.78±0.10(Predicted) |
Research Application of CAS:875-97-8 | 2-[(5S)-2,4-dioxothiazolidin-5-yl]acetate
Antibacterial Activity
[(2,4-Dioxo-thiazolidin-5-yl)-acetic acid] derivatives have shown notable antibacterial activity. A study by Trotsko et al. (2018) synthesized derivatives of this compound and found them generally effective against Gram-positive bacterial strains, with some derivatives exhibiting antibacterial activity comparable to commonly used drugs like oxacillin and cefuroxime (Trotsko et al., 2018). Similarly, Alhameed et al. (2019) reported that certain derivatives demonstrated weak to moderate antibacterial activity against Gram-negative bacteria and antifungal activity, with one compound showing significant antibacterial activity against Gram-positive bacteria (Alhameed et al., 2019).
Anticonvulsant Properties
Mishchenko et al. (2020) explored the anticonvulsant properties of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores. They found that some compounds showed excellent anticonvulsant activity in models of pentylenetetrazole-induced seizures and maximal electroshock seizure tests (Mishchenko et al., 2020).
Fungicidal Properties
Alauddin and Hayat (2012) prepared derivatives of 2,4-dioxo-thiazolidin-5-yl-acetic acid and screened them for fungicidal activity against various fungi, indicating its potential as a fungicide (Alauddin & Hayat, 2012).
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