CAS:83541-68-8 | (-)-DIISOPROPYL-L-MALATE

Introduction of CAS:83541-68-8 | (-)-DIISOPROPYL-L-MALATE

(-) -diisopropyl ester - L-malate is a compound commonly expressed as (L) -diisopropionate malate. It is an ester compound formed from (-) -diisopropyl alcohol and malic acid.

This compound is often used in the food industry and pharmaceutical preparation as a raw material for spices or medicines. Malates are commonly used to prepare substances that taste or smell like apples. Diisopropyl ester is a chiral compound, indicating that it exists in two enantiomers, one of which is formed from L-malic acid.

Specification of CAS:83541-68-8 | (-)-DIISOPROPYL-L-MALATE

Research Application of CAS:83541-68-8 | (-)-DIISOPROPYL-L-MALATE

Enantioselective Synthesis of Lactone Lignans : Diisopropyl malate is the starting point for synthesizing enantiomerically pure α-hydroxylated lactone lignans. These compounds, with potential applications in cancer research, have shown inhibition of HT29 colon cancer cell proliferation (Sefkow, Raschke, & Steiner, 2003).

Malate Dehydrogenase Study : Research on malate dehydrogenase, an enzyme with significant roles in cellular metabolism, has utilized malate compounds. This enzyme shows activity peaks in mitochondrial and peroxisomal fractions, indicating its significance in cellular biochemical pathways (Yamazaki & Tolbert, 1969).

Malic Acid Production by Yeast : Diisopropyl malate derivatives are relevant in the study of malic acid production using genetically engineered Saccharomyces cerevisiae. This research is crucial for biotechnological applications in producing biomass-derived chemicals (Zelle et al., 2008).

. Combustion and Emissions in Engines : The addition of diisopropyl ether (related to diisopropyl malate in its structural properties) to fuel blends has been studied to understand its effects on combustion, performance, emissions, and operating range in homogeneous charged compression ignition (HCCI) engines. This research contributes to automotive engineering and environmental studies (Uyumaz et al., 2020).

Aspartate Shuttle in Peroxisomes : Research involving malate/aspartate shuttle systems in leaf peroxisomes provides insights into the cellular metabolic processes. This study evaluates the shuttle's role in supplying NADH to peroxisomal matrix, crucial for understanding cellular energy metabolism (Schmitt & Edwards, 1983).

Chiral Auxiliary for Synthesis : Diisopropyl L-malate has been used as a chiral auxiliary in the dynamic kinetic resolution of α-bromo esters and asymmetric syntheses, relevant in organic chemistry and pharmaceutical research (Kang et al., 2011).

Isoenzyme Partitioning Study : Research on the partitioning of malate dehydrogenase isoenzymes into glyoxysomes, mitochondria, and chloroplasts contributes to our understanding of metabolic pathways in plants and their evolutionary aspects (Gietl, 1992).

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