CAS:4808-30-4 | BIS(TRI-N-BUTYLTIN)SULFIDE

Introduction of CAS:4808-30-4 | BIS(TRI-N-BUTYLTIN)SULFIDE

Tributyltin sulfide (TBT) is a chemical compound composed of tin and sulfur. It is a colorless and odorless solid that is soluble in organic solvents. It has many uses in industry, such as in the manufacture of polymers, paints, and adhesives. It is also used as an antifouling agent in marine paints and as an agricultural fungicide. Due to its toxic properties, its use has been restricted in many countries.

Specification of CAS:4808-30-4 | BIS(TRI-N-BUTYLTIN)SULFIDE

Research Application of CAS:4808-30-4 | BIS(TRI-N-BUTYLTIN)SULFIDE

Reproductive Toxicity: Tributyltin (TBT) exposure has been shown to significantly affect Leydig cell development in rats, leading to reduced serum testosterone levels and altered Leydig and Sertoli cell gene expression, suggesting reproductive toxicity (Wu et al., 2017).

Environmental Impact and Human Exposure: TBT, used in industries like paper mills and marine antifouling agents, has been found in marine and freshwater ecosystems, potentially exceeding toxicity levels. It's a significant environmental concern due to its persistence, bioaccumulation, and endocrine-disruptive characteristics, with potential human exposure through the food chain (Antízar-Ladislao, 2008).

Toxicity in Freshwater Fish: TBT has been identified as a powerful aquatic contaminant in tropical ecosystems, affecting freshwater fish like Astyanax bimaculatus, with morphological effects observed in the liver and changes in acetylcholinesterase activity (Oliveira Ribeiro et al., 2002).

Binding Protein in Marine Fish: In Japanese flounder, a novel tributyltin-binding protein (TBT-bp) has been identified, suggesting a mechanism for TBT accumulation and response in marine organisms (Shimasaki et al., 2002).

Use in Luminescent Biosensors: TBT has been utilized in the development of luminescent biosensors. Escherichia coli gene-fusion libraries have identified genes that increase light emission upon exposure to TBT, potentially aiding in the detection of environmental contamination (Briscoe et al., 1995).

Impact on Shallow Lake Ecosystems: Research indicates that TBT may cause significant damage to freshwater ecosystems, potentially leading to a shift in the ecological regime of shallow lakes by impacting the population of grazing organisms (Sayer et al., 2006).

Immunotoxic Effects: Studies on murine thymocytes suggest that tributyltin-chloride exhibits immunotoxic effects through oxidative stress, mitochondrial membrane depolarization, and caspase-dependent apoptotic pathways (Sharma & Kumar, 2014).

Environmental Remediation Techniques: Various methods for remediating TBT contamination in soil and water have been explored, including thermal treatment, biodegradation, advanced chemical oxidation, and physio-chemical adsorption. These techniques focus on addressing the persistent environmental impact of TBT (Du et al., 2014).

Bacterial Resistance Mechanisms: In Pseudomonas stutzeri, a multidrug efflux pump, TbtABM, has been associated with resistance to TBT, highlighting a bacterial response mechanism to this environmental contaminant (Jude et al., 2004).

Gene Expression Responses in Tetrahymena thermophila: Exposure to TBT has led to the identification of differentially expressed genes in Tetrahymena thermophila, providing a basis for using this organism as a biomonitor for TBT in freshwater environments (Feng et al., 2007).

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