CAS:175277-18-6 | 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE

Introduction of CAS:175277-18-6 | 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE

The structure of benzohydrazide derivatives, including those related to 4-(trifluoromethoxy)benzohydrazide, has been elucidated through X-ray crystallography. This method provides detailed insights into the molecular conformations and the nature of intramolecular and intermolecular interactions, which are crucial for understanding the chemical behavior and reactivity of these compounds

Specification of CAS:175277-18-6 | 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE

Research Application of CAS:175277-18-6 | 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE

Electron-withdrawing Properties : The trifluoromethoxy group, related to 4-(Trifluoromethoxy)benzohydrazide, is superior to both methoxy and trifluoromethyl groups in promoting hydrogen/metal permutation. It exerts a long-range effect, considerably lowering the basicity of arylmetal compounds even when located in meta or para positions (Castagnetti & Schlosser, 2002).

Synthesis of Functionalized Compounds : Benzohydrazide, including 4-(Trifluoromethoxy)benzohydrazide, is used in one-pot four-component reactions to create functionalized compounds like 1-benzamido-1,4-dihydropyridines and 1-benzamidospiro[indoline-3,4'-pyridines], which could have various applications (Sun et al., 2014; Wang et al., 2014).

Photoresponsive Materials : A study on (E)-N'-(anthracene-10-ylmethylene)-3,4,5-tris(dodecyloxy)benzohydrazide, related to 4-(Trifluoromethoxy)benzohydrazide, demonstrated its use in creating multi-responsive organogels showing changes in properties like fluorescence intensity and mechanical strength upon irradiation (Mondal et al., 2015).

Antioxidant and Enzymatic Activities : Methoxy-substituted benzohydrazide derivatives have been synthesized and evaluated for antioxidant and α-glucosidase inhibitory activities. This research suggests potential for similar derivatives of 4-(Trifluoromethoxy)benzohydrazide in biological applications (Prachumrat et al., 2018).

Antimicrobial and Antifungal Properties : Hydrazones derived from 4-(Trifluoromethyl)benzohydrazide have shown potent antimicrobial and antifungal activities, suggesting the potential of 4-(Trifluoromethoxy)benzohydrazide derivatives in pharmaceutical applications (Krátký et al., 2017).

Synthesis of Heterocyclic Compounds : Benzohydrazide is used in microwave-assisted reactions to synthesize 1,2,4-triazole derivatives, which have applications in medicinal chemistry and pharmacology (Panda et al., 2022).

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