Introduction of CAS:1196156-59-8 | 2,6-Dibromo-4-chloropyridine
2,6-Dibromo-4-chloropyridine (2,6-DBCP) is an organic compound that is commonly used in various scientific research applications. It is a colorless solid that is soluble in organic solvents, such as ethanol and acetone. 2,6-DBCP has a wide range of applications, from the synthesis of pharmaceuticals to the production of agrochemicals. It is also used as a reagent in organic synthesis and as a catalyst in the synthesis of polymers.
Specification of CAS:1196156-59-8 | 2,6-Dibromo-4-chloropyridine
|
ITEMS |
SPECIFICATION |
|
Purity |
97% |
|
Boiling point |
276.5±35.0 °C(Predicted) |
|
Density |
2.136±0.06 g/cm3(Predicted) |
|
Acidity coefficient (pKa) |
-2.93±0.10(Predicted) |
|
Storage condition |
under inert gas (nitrogen or Argon) at 2-8°C |
Research Application of CAS:1196156-59-8 | 2,6-Dibromo-4-chloropyridine
Synthesis and Coordination Chemistry
2,6-Dibromo-4-chloropyridine serves as a versatile precursor in the synthesis of complex ligands, such as 2,6-di(pyrazolyl)pyridines, which are valuable in coordination chemistry. These ligands have been utilized to create luminescent lanthanide compounds useful in biological sensing and iron complexes that exhibit unique thermal and photochemical spin-state transitions, highlighting their potential in materials science and sensor technology (Halcrow, 2005).
Regioselective Lithiation
The compound has been instrumental in developing methodologies for regioselective lithiation, a critical step in organic synthesis. For instance, the use of BuLi-LiDMAE superbase has demonstrated unprecedented C-6 lithiation of 2-chloropyridine, a closely related compound, thereby opening new pathways for the synthesis of chlorinated pyridinic and bis-heterocyclic synthons. This advancement underscores the importance of 2,6-Dibromo-4-chloropyridine in facilitating novel synthetic routes (Choppin, Gros, & Fort, 2000).
Development of Functional Materials
Research into the derivatives of 2,6-di(pyrazolyl)pyridines, which can be synthesized from 2,6-Dibromo-4-chloropyridine, has led to the creation of multifunctional spin-crossover switches, emissive f-element podand centers for biomedical sensors, and the self-assembly of functional soft materials. These developments highlight the compound's significant role in the creation of novel materials with potential applications in electronics, sensing, and healthcare (Halcrow, 2014).
Catalysis
The synthesis of pincer bis-carbene ligands from 2,6-bis(arylimidazolium)pyridine dibromide, which could potentially be derived from 2,6-Dibromo-4-chloropyridine, has led to the development of ruthenium pincer complexes. These complexes have shown promising catalytic activity in the transfer hydrogenation of carbonyl compounds, indicating the potential of 2,6-Dibromo-4-chloropyridine in catalysis research and its application in organic transformations (Danopoulos, Winston, & Motherwell, 2002).
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