Introduction of CAS:161957-56-8 | 3-Bromo-2-fluorobenzoic acid
3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).
Specification of CAS:161957-56-8 | 3-Bromo-2-fluorobenzoic acid
|
ITEMS |
SPECIFICATION |
|
Boiling Point |
298.2±25.0 °C(Predicted) |
|
Melting point |
168 °C |
|
density |
1.789±0.06 g/cm3(Predicted) |
|
PSA |
37.30000 |
|
Solubility |
Chloroform(Slightly),DMSO(Slightly),Methanol(Slightly, Sonicated) |
|
LogP |
2.28640 |
|
Form |
powder to crystal |
|
Color |
White to Light yellow |
|
Acidity coefficient (pKa) |
2.88±0.10(Predicted) |
|
Stability |
Sealed in dry,Room Temperature |
Related Articles of CAS:161957-56-8 | 3-Bromo-2-fluorobenzoic acid
bromo-2-fluorobenzoic acid is an organic synthetic intermediate with the molecular formula C7H4BrFO2, molecular weight 219.008, density 1.79, and melting point of 168°C. Storage method: Close Chemicalbook, cool, ventilated and dry place, and avoid direct contact with oxide. 3-bromo-2-fluorobenzoic acid can dissolve methanol, dimethyl sulfoxide,N, N-dimethylformamide; It also has a certain solubility in water.
The main use of 3-bromo-2-fluorobenzoic acid is to use the three functional groups of its molecule to carry out various transformations to synthesize other pharmaceutically useful pharmaceutical molecular intermediates.
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