CAS 144-48-9 2-Iodoacetamide

Introduction and application of CAS 144-48-9 2-Iodoacetamide

Description：
2-Iodoacetamide is an alkylating agent used for peptide mapping purposes. Its actions are similar to those of iodoacetate. It is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds. Also used in ubiquitin studies as an inhibitor of deubiquitinase enzymes (DUBs) because it alkylates the cysteine residues at the DUB active site.

Synonyms
USAF D-1;
carbamoylmethyl iodide;
Monoiodoacetamide;
2-iodoacetamido;
Iodoacetamide;
Acetamide, 2-iodo-;
ACETAMIDE,2-IODO;
2-Iodo-acetamide;
2-IodoacetaMide;
Surauto;

Application

1, Can be used as a protease inhibitor

CH2ICONH2, like iodoacetic acid, irreversibly inhibits Shases through the following reactions.

R - SH + ICH2CONH2 - R - S - CH2CONH2 + HI

2, Alkylating reagent for histidine and cysteine in proteomics, used in peptide sequencing and enzyme inhibitors. It is also used in organic synthesis.

Specification of CAS 144-48-9 2-Iodoacetamide

Package and transportation of CAS 144-48-9 2-Iodoacetamide
Transportation: by courier/ by air/ by sea

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