Introduction and application of CAS No.1223405-08-0 | LOXO-101 (sulfate)
A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.
Synonyms:
Larotrectinib sulphate;
(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamidesulfate(1:1);
Larotrectinib/LOXO101/ARRY470sulfate;
(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamidesulfate;
ARRY470)sulfate;Larotrectinibsulfate;Larotrectinib(LOXO101;
Larotrectinib(LOXO-101)sulfate
Specification of CAS No.1223405-08-0 | LOXO-101 (sulfate)
|
ITEMS |
SPECIFICATION |
|
CAS |
1223405-08-0 |
|
MF |
C21H24F2N6O6S |
|
MW |
526.52 |
Package and transportation of Introduction and application of CAS No.1223405-08-0 | LOXO-101 (sulfate)
Package:0.1g,1g,5g,25g,100g,500g,1kg
Transportation: by courier/ by air/ by sea
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