Introduction and application of CAS:285983-48-4 | Doramapimod
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with a Kd of 0.1 nM. It is 330 times more selective than JNK2. It weakly inhibits c-RAF, Fyn and Lck, and also weakly inhibits ERK-1 and SYK. , IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.
Specification of CAS:285983-48-4 | Doramapimod
| Item | Specification |
Melting point: 142-143°C
Boiling point: 631.6±55.0°C(Predicted)
Density: 1.20±0.1g/cm3(Predicted)
Storage conditions: Sealedindry, Storeinfreezer, under-20°C
Solubility: Soluble in DMSO (up to 50mg/ml) or ethanol (up to 30mg/ml).
Form: solid
Acidity coefficient (pKa): 13.47±0.70 (Predicted)
Color: white or off-white
Package and transportation of CAS:285983-48-4 | Doramapimod
Transportation: by courier/ by air/ by sea.
Related articles of CAS:285983-48-4 | Doramapimod
Human p38α mitogen-activated protein kinase in the Asp168-Phe169-Gly170-in (DFG-in) state can bind allosteric inhibitor Doramapimod
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